Gradient Boosting Machine (GBM) modeling is a powerful machine learning technique for advanced root cause analysis in manufacturing. It will uncover problems that would be missed by regression-based statistical modelling techniques and single tree methods, but can easily be used by analysts with no expertise in statistics and modelling to solve complex problems. It is an excellent choice for advanced equipment commonality analysis and will detect interactions between process factors (for example, machines, recipes, process dates) that are responsible for bad product. It can also be used to identify complex nonlinear relationships and interactions between product quality measurements (for example, yield, defects, field returns) and upstream measurements from the product, process, equipment, component, material, or environment.